Enhanced XAO: the ontology of Xenopus anatomy and development underpins more accurate annotation of gene expression and queries on Xenbase

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چکیده

The African clawed frogs Xenopus laevis and Xenopus tropicalis are prominent animal model organisms. Xenopus research contributes to the understanding of genet ic, developmental and molecular mechanisms underlying human disease. The Xenopus Anatomy Ontology (XAO) reflects the anatomy and embryological development of Xenopus. The XAO provides consistent terminology that can be applied to anatomical feature descript ions along with a set of relat ionships that indicate how each anatomical ent ity is related to others in the embryo, tadpole, or adult frog. The XAO is integral to the funct ionality of Xenbase (http://www.xenbase.org [10 ]), the Xenopus model organism database. DOI 10.1186/2041-1480-4-31 [11] Short Tit le J Biomed Semant ics Source URL: http://www.antibodychain.com/content/enhanced_xao_ontology_xenopus_anatomy_and_development_underpins_more_accurate_annotation_gen Links: [1] http://www.antibodychain.com/content/enhanced_xao_ontology_xenopus_anatomy_and_development_underpins_more_accurate_annotation_gen 1 [2] http://www.antibodychain.com/biblio/author/154649 [3] http://www.antibodychain.com/biblio/author/118489 [4] http://www.antibodychain.com/biblio/author/118488 [5] http://www.antibodychain.com/biblio/author/118491 [6] http://www.antibodychain.com/biblio/author/154650 [7] http://www.antibodychain.com/biblio/author/154651 [8] http://www.antibodychain.com/biblio/author/112510 [9] http://www.antibodychain.com/biblio/author/118498 [10] http://www.xenbase.org [11] http://dx.doi.org/10.1186/2041-1480-4-31

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Enhanced XAO: the ontology of Xenopus anatomy and development underpins more accurate annotation of gene expression and queries on Xenbase

BACKGROUND The African clawed frogs Xenopus laevis and Xenopus tropicalis are prominent animal model organisms. Xenopus research contributes to the understanding of genetic, developmental and molecular mechanisms underlying human disease. The Xenopus Anatomy Ontology (XAO) reflects the anatomy and embryological development of Xenopus. The XAO provides consistent terminology that can be applied ...

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Xenbase: a Xenopus biology and genomics resource

Xenbase (www.xenbase.org) is a model organism database integrating a diverse array of biological and genomic data on the frogs, Xenopus laevis and Xenopus (Silurana) tropicalis. Data is collected from other databases, high-throughput screens and the scientific literature and integrated into a number of database modules covering subjects such as community, literature, gene and genomic analysis. ...

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Xenbase: gene expression and improved integration

Xenbase (www.xenbase.org), the model organism database for Xenopus laevis and X. (Silurana) tropicalis, is the principal centralized resource of genomic, development data and community information for Xenopus research. Recent improvements include the addition of the literature and interaction tabs to gene catalog pages. New content has been added including a section on gene expression patterns ...

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Xenbase: expansion and updates of the Xenopus model organism database

Xenbase (http://www.xenbase.org) is a model organism database that provides genomic, molecular, cellular and developmental biology content to biomedical researchers working with the frog, Xenopus and Xenopus data to workers using other model organisms. As an amphibian Xenopus serves as a useful evolutionary bridge between invertebrates and more complex vertebrates such as birds and mammals. Xen...

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Background: Members of the eukaryotic Hsp90 family function as important molecular chaperones in the assembly, folding and activation of cellular signaling in development. Two hsp90 genes, hsp90 alpha and hsp90 beta, have been identified in fish and homeothermic vertebrates but not in poikilothermic vertebrates. In the present study, the expression of hsp90 alpha and hsp90 beta genes in Xenopus...

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تاریخ انتشار 2016